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The drug, which is related to the antidepressant family, affects serotonin and several other ain chemicals, though its not clear how that increases sex drive. We dont know specifically what the exact mechanism of action is but we believe it acts on ain chemicals that have a role in human sexual response, said Dr. Peter Piliero, executive director for Boehringer s medical affairs. Since the launch of Viagra in 1998, more than two dozen experimental therapies have been studied for so-called female sexual dysfunction, a market which some analysts estimate at 2 billion. Dr. Elizabeth Kavaler, a urologist at Lenox Hill Hospital in New York, says arousal in women is so complicated that it may be unrealistic to expect a pill to completely address sexual problems. Its a fairly complicated area, unlike in mens sexual dysfunction where theres a major mechanical concern, said Kavaler. In women theres no mechanical concern, so if shes not having a successful sex life, where is the problem? Pharmaceutical approaches to boosting female sexual libido have evolved over time. Initially, most treatments aimed to increase blood flow to the genitals, similar to Viagra. A second wave of would-be blockbusters focused on boosting hormones, including testosterone, which is linked to sexual interest.
Flibanserin is the first drug to approach the problem through ain chemistry. The FDA has approved an unusual handheld vacuum device that increases blood flow to the clitoris to increase sexual arousal. But all drug therapies have fallen short so far. In 2004, Pfizer halted its study of Viagra in women due to inconclusive results. Later that year an FDA panel rejected Procter Gambles testosterone patch Intrinsa, due to risks of heart disease and cancer. Smaller companies are currently developing creams and nasal sprays to increase female libido. Medical surveys have estimated more than 40% of women suffer from some form of sexual dysfunction; Boehringer estimates as many as one in 10 women could be helped by its drug. Boehringer tried to zero in on the chemical aspect of sexual dysfunction by only testing its drug on premenopausal women who were in stable relationships and not taking other medications. Despite wanting to have a sexual relationship, the women enrolled in company studies reported a persistent lack of desire that caused them distress or interpersonal difficulty.
Leonore Tiefer, a psychiatry professor at New York University who runs a private sex therapy practice, believes drugmakers have oversimplified female sexuality. She says in most cases lack of sex drive has more to do with the quality of ones relationship and lifestyle than ain chemicals. During the public comment period at Fridays meeting, Tiefer will ask the FDA to reject flibanserin, arguing it offers meager benefits for women with unknown long-term risks.
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Lady Kate Davson Centre gave the Homily. Archbishop-elect, Martin Kivuva shows the book Year of the Priest after he launched it flanked by Prof Lukwata, the book editor, Jan 15, 2015 Feb 5, 2015: The Catholic Bishop of Ngong Diocese, Rt. Rev. John Oballa Owaa launched the year of consecrated life here at the University.